Tumor-Microenvironment Interactions

Endothelial and Accessory Cell Interactions in Neuroblastoma Tumor Microenvironment

Transcriptional Analysis of Reciprocal Tumor-Microenvironment Interactions in Glioblastoma

vi Chapter 1: Introduction 1 Chapter 1 References 18 Chapter 2: Hitting Them Where They Live: Targeting the Glioblastoma Perivascular Stem Cell Niche 24 Chapter 2 References 42 Chapter 3: Methods of Transcriptional Analysis 50 Chapter 3 References 67 Chapter 4: Discovery of PDE7B as a novel effector of GBM growth by computational deconvolution of an in vitro physical 71 coculture system. Chapte...

Tumor-lymphatic interactions in an activated stromal microenvironment.

Metastasis to lymph nodes is a common feature of many human tumors and may facilitate dissemination to other parts of the body. Peritumoral lymphatics, which are located at the periphery of a primary tumor, appear to be anything but peripheral for metastasis, as recent studies have highlighted their critical role in disseminating tumor cells to local lymph nodes. The metastatic process, includi...

Tumor Microenvironment

Abstract While genetic changes are critical for the malignant transformation of epithelial cells, the microenvironment in which the cells reside also governs carcinogenesis. Most tumors arise within a cellular microenvironment characterized by suppressed host immunity, dysregulated inflammation, and increased production of cellular growth and survival factors that induce angiogenesis and inhibi...

The brain tumor microenvironment.

High-grade brain tumors are heterogeneous with respect to the composition of bona fide tumor cells and with respect to a range of intermingling parenchymal cells. Glioblastomas harbor multiple cell types, some with increased tumorigenicity and stem cell-like capacity. The stem-like cells maybe the cells of origin for tumor relapse. However, the tumor-associated parenchymal cells such as vascula...